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DeCS
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Descriptor English:
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Giant Cells
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Descriptor Spanish:
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Células Gigantes
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Descriptor Portuguese:
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Células Gigantes
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Synonyms English:
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Giant Cells, Multinucleated
Multinucleated Giant Cells
Polykaryocytes
Syncytium
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Tree Number:
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A11.502
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Definition English:
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Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus. |
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Indexing Annotation English:
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any very large cell; A 11 qualif
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History Note English:
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90
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Allowable Qualifiers English:
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Record Number:
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24694
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Unique Identifier:
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D015726
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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